Transcription factors with Perturb-seq knockdown data for ENSG00000289509. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289509 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289509, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:98,325,036–98,325,386 | at TSS | At TSS | 70 | |
| chr3:98,326,618–98,327,012 | 1.4 kb | Proximal (<10kb) | 27 | |
| chr3:98,328,988–98,329,852 | 3.8 kb | Proximal (<10kb) | 238 | |
| chr3:98,521,861–98,523,430 | 197.7 kb | Distal (>10kb) Multiome | 832 | |
| chr3:98,592,698–98,594,265 | 268.5 kb | Distal (>10kb) Multiome | 864 |
Genomic view of the ENSG00000289509 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.