Transcription factors with Perturb-seq knockdown data for ENSG00000289501. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289501 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289501, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:98,823,806–98,825,719 | 7.2 kb | Proximal (<10kb) | 352 | |
| chr6:98,827,389–98,828,099 | 4.8 kb | Proximal (<10kb) | 118 | |
| chr6:98,828,971–98,829,435 | 3.5 kb | Proximal (<10kb) | 81 | |
| chr6:98,830,904–98,836,517 | at TSS | At TSS | 693 | |
| chr6:98,839,885–98,840,036 | 7.0 kb | Proximal (<10kb) | 60 | |
| chr6:98,842,412–98,843,096 | 9.5 kb | Proximal (<10kb) | 114 |
Genomic view of the ENSG00000289501 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.