Transcription factors with Perturb-seq knockdown data for ENSG00000289358. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289358 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289358, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:109,315,991–109,316,929 | 21.3 kb | Distal (>10kb) Multiome | 194 | |
| chr3:109,323,906–109,326,095 | 12.5 kb | Distal (>10kb) Multiome | 218 | |
| chr3:109,334,254–109,335,769 | 2.0 kb | Proximal (<10kb) | 43 | |
| chr3:109,336,338–109,336,883 | 886 bp | At TSS | 68 | |
| chr3:109,337,006–109,338,173 | 113 bp | At TSS Multiome | 155 | |
| chr3:109,338,868–109,339,179 | 1.1 kb | Proximal (<10kb) | 5 | |
| chr3:109,339,680–109,340,427 | 1.9 kb | Proximal (<10kb) | 127 | |
| chr3:109,340,697–109,341,112 | 2.9 kb | Proximal (<10kb) | 4 |
Genomic view of the ENSG00000289358 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.