Transcription factors with Perturb-seq knockdown data for ENSG00000289205. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289205 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289205, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:188,028,333–188,029,062 | 4.7 kb | Proximal (<10kb) | 30 | |
| chr2:188,032,198–188,034,514 | 1.4 kb | Proximal (<10kb) Multiome | 375 | |
| chr2:188,034,699–188,035,246 | 906 bp | At TSS | 47 | |
| chr2:188,035,362–188,036,487 | 1.6 kb | Proximal (<10kb) | 32 | |
| chr2:188,172,925–188,173,454 | 139.4 kb | Distal (>10kb) Multiome | 93 | |
| chr2:188,181,184–188,182,353 | 147.9 kb | Distal (>10kb) Multiome | 267 | |
| chr2:188,291,086–188,293,283 | 259.0 kb | Distal (>10kb) Multiome HiCAR | 756 | |
| chr2:188,303,125–188,304,072 | 270.0 kb | Distal (>10kb) Multiome | 323 |
Genomic view of the ENSG00000289205 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.