Transcription factors with Perturb-seq knockdown data for ENSG00000289199. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289199 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289199, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:56,624,898–56,625,604 | at TSS | At TSS | 210 | |
| chr20:56,626,234–56,627,000 | 1.2 kb | Proximal (<10kb) | 168 | |
| chr20:56,628,380–56,631,136 | 3.3 kb | Proximal (<10kb) | 551 | |
| chr20:56,631,439–56,631,930 | 6.4 kb | Proximal (<10kb) | 111 | |
| chr20:56,632,340–56,632,526 | 7.3 kb | Proximal (<10kb) | 23 | |
| chr20:56,632,796–56,633,063 | 7.7 kb | Proximal (<10kb) | 12 |
Genomic view of the ENSG00000289199 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.