Transcription factors with Perturb-seq knockdown data for ENSG00000289179. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289179 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289179, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:174,204,100–174,204,651 | 9.8 kb | Proximal (<10kb) | 58 | |
| chr4:174,210,451–174,210,677 | 3.8 kb | Proximal (<10kb) | 48 | |
| chr4:174,211,511–174,212,067 | 2.4 kb | Proximal (<10kb) | 48 | |
| chr4:174,212,329–174,213,129 | 1.3 kb | Proximal (<10kb) | 24 | |
| chr4:174,213,405–174,215,117 | at TSS | At TSS | 337 | |
| chr4:174,216,349–174,216,720 | 1.9 kb | Proximal (<10kb) | 78 | |
| chr4:174,216,830–174,218,791 | 2.4 kb | Proximal (<10kb) | 383 | |
| chr4:174,222,343–174,222,750 | 7.9 kb | Proximal (<10kb) | 107 |
Genomic view of the ENSG00000289179 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.