Transcription factors with Perturb-seq knockdown data for ENSG00000288898. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000288898 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000288898, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:218,658,668–218,660,011 | 249.5 kb | Distal (>10kb) Multiome | 870 | |
| chr2:218,671,689–218,672,558 | 237.1 kb | Distal (>10kb) Multiome | 794 | |
| chr2:218,710,272–218,711,420 | 198.3 kb | Distal (>10kb) Multiome | 957 | |
| chr2:218,781,682–218,782,718 | 127.0 kb | Distal (>10kb) Multiome | 674 | |
| chr2:218,798,810–218,799,640 | 109.9 kb | Distal (>10kb) Multiome | 163 | |
| chr2:218,799,866–218,800,388 | 108.8 kb | Distal (>10kb) Multiome | 82 | |
| chr2:218,860,491–218,861,382 | 48.1 kb | Distal (>10kb) Multiome | 241 | |
| chr2:218,883,560–218,884,239 | 25.2 kb | Distal (>10kb) Multiome | 190 | |
| chr2:218,892,714–218,893,400 | 16.2 kb | Distal (>10kb) Multiome | 591 | |
| chr2:218,898,077–218,898,730 | 10.8 kb | Distal (>10kb) Multiome | 624 | |
| chr2:218,908,757–218,909,543 | 23 bp | At TSS Multiome | 885 | |
| chr2:218,959,145–218,960,352 | 50.4 kb | Distal (>10kb) Multiome | 416 | |
| chr2:218,962,902–218,964,278 | 54.2 kb | Distal (>10kb) Multiome | 768 | |
| chr2:218,979,814–218,980,492 | 71.0 kb | Distal (>10kb) Multiome | 499 | |
| chr2:218,984,382–218,985,013 | 75.5 kb | Distal (>10kb) Multiome | 126 | |
| chr2:218,992,930–218,994,312 | 84.4 kb | Distal (>10kb) Multiome HiCAR | 265 | |
| chr2:218,995,885–218,998,018 | 87.1 kb | Distal (>10kb) Multiome | 534 | |
| chr2:218,998,611–219,003,562 | 92.9 kb | Distal (>10kb) Multiome | 941 | |
| chr2:219,057,853–219,058,462 | 149.0 kb | Distal (>10kb) Multiome | 469 | |
| chr2:219,060,260–219,061,256 | 151.7 kb | Distal (>10kb) Multiome | 240 | |
| chr2:219,159,910–219,161,297 | 251.4 kb | Distal (>10kb) Multiome | 901 | |
| chr2:219,176,168–219,177,450 | 267.7 kb | Distal (>10kb) Multiome | 999 | |
| chr2:219,177,596–219,178,930 | 269.1 kb | Distal (>10kb) Multiome | 930 | |
| chr2:219,206,194–219,207,456 | 297.7 kb | Distal (>10kb) Multiome | 861 |
Genomic view of the ENSG00000288898 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.