Transcription factors with Perturb-seq knockdown data for ENSG00000288015. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000288015 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000288015, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:57,629,262–57,630,444 | 1600.6 kb | Distal (>10kb) Multiome HiCAR | 252 | |
| chr13:57,630,757–57,635,039 | 1598.4 kb | Distal (>10kb) Multiome HiCAR | 464 | |
| chr13:59,012,604–59,013,258 | 217.7 kb | Distal (>10kb) Multiome | 165 | |
| chr13:59,230,121–59,231,605 | at TSS | At TSS | 162 | |
| chr13:59,352,519–59,353,414 | 122.3 kb | Distal (>10kb) Multiome | 148 | |
| chr13:59,354,733–59,356,147 | 124.7 kb | Distal (>10kb) Multiome | 220 | |
| chr13:59,357,830–59,358,460 | 127.6 kb | Distal (>10kb) Multiome | 82 |
Genomic view of the ENSG00000288015 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.