Transcription factors with Perturb-seq knockdown data for ENSG00000287778. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000287778 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000287778, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:10,944,088–10,944,677 | 485.1 kb | Distal (>10kb) Multiome HiCAR | 71 | |
| chr4:11,252,019–11,252,656 | 177.3 kb | Distal (>10kb) Multiome HiCAR | 92 | |
| chr4:11,422,882–11,424,297 | 5.9 kb | Proximal (<10kb) Multiome | 181 | |
| chr4:11,427,259–11,428,040 | 1.6 kb | Proximal (<10kb) | 115 | |
| chr4:11,428,150–11,429,940 | 574 bp | At TSS Multiome | 409 | |
| chr4:12,614,679–12,615,500 | 1185.5 kb | Distal (>10kb) Multiome HiCAR | 105 |
Genomic view of the ENSG00000287778 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.