Transcription factors with Perturb-seq knockdown data for ENSG00000287117. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000287117 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000287117, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:9,498,390–9,498,978 | 193.2 kb | Distal (>10kb) Multiome | 64 | |
| chr4:9,531,997–9,533,096 | 159.5 kb | Distal (>10kb) Multiome | 143 | |
| chr4:9,690,938–9,692,240 | 73 bp | At TSS Multiome | 211 | |
| chr4:9,696,072–9,696,252 | 4.3 kb | Proximal (<10kb) | 5 | |
| chr4:10,018,674–10,019,611 | 327.2 kb | Distal (>10kb) Multiome HiCAR | 533 |
Genomic view of the ENSG00000287117 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.