Transcription factors with Perturb-seq knockdown data for ENSG00000286787. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000286787 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000286787, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:833,367–834,334 | 284.8 kb | Distal (>10kb) Multiome | 839 | |
| chr20:844,437–845,353 | 273.9 kb | Distal (>10kb) Multiome | 299 | |
| chr20:884,981–885,530 | 233.3 kb | Distal (>10kb) Multiome HiCAR | 183 | |
| chr20:955,007–955,547 | 163.2 kb | Distal (>10kb) Multiome HiCAR | 24 | |
| chr20:1,001,978–1,002,815 | 116.0 kb | Distal (>10kb) Multiome | 124 | |
| chr20:1,061,388–1,061,918 | 56.8 kb | Distal (>10kb) Multiome | 105 | |
| chr20:1,108,503–1,108,724 | 9.8 kb | Proximal (<10kb) | 210 | |
| chr20:1,114,166–1,114,356 | 4.1 kb | Proximal (<10kb) | 95 | |
| chr20:1,118,327–1,119,071 | 75 bp | At TSS Multiome | 1066 | |
| chr20:1,184,818–1,186,197 | 67.3 kb | Distal (>10kb) Multiome | 557 | |
| chr20:1,225,365–1,226,806 | 107.3 kb | Distal (>10kb) Multiome | 616 | |
| chr20:1,266,029–1,266,958 | 147.9 kb | Distal (>10kb) Multiome | 499 | |
| chr20:1,300,911–1,301,500 | 182.8 kb | Distal (>10kb) Multiome | 171 | |
| chr20:1,313,163–1,313,790 | 195.0 kb | Distal (>10kb) Multiome | 428 | |
| chr20:1,325,008–1,326,107 | 206.9 kb | Distal (>10kb) Multiome | 901 | |
| chr20:1,392,628–1,393,457 | 274.6 kb | Distal (>10kb) Multiome | 799 |
Genomic view of the ENSG00000286787 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.