Transcription factors with Perturb-seq knockdown data for ENSG00000286757. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000286757 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000286757, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:99,605,931–99,607,157 | 349.2 kb | Distal (>10kb) Multiome HiCAR | 845 | |
| chr13:99,657,854–99,658,963 | 297.3 kb | Distal (>10kb) Multiome HiCAR | 252 | |
| chr13:99,686,744–99,688,098 | 268.7 kb | Distal (>10kb) Multiome HiCAR | 332 | |
| chr13:99,818,120–99,818,590 | 137.5 kb | Distal (>10kb) Multiome | 93 | |
| chr13:99,949,757–99,949,969 | 7.2 kb | Proximal (<10kb) | 66 | |
| chr13:99,955,497–99,958,187 | 1.9 kb | Proximal (<10kb) Multiome | 501 | |
| chr13:99,958,757–99,959,091 | 1.6 kb | Proximal (<10kb) | 81 | |
| chr13:99,959,666–99,960,219 | 2.5 kb | Proximal (<10kb) | 111 | |
| chr13:99,970,037–99,972,702 | 16.1 kb | Distal (>10kb) Multiome | 629 | |
| chr13:99,978,424–99,982,746 | 23.3 kb | Distal (>10kb) Multiome | 812 | |
| chr13:99,990,093–99,992,597 | 36.1 kb | Distal (>10kb) Multiome | 378 | |
| chr13:99,996,965–99,998,156 | 41.6 kb | Distal (>10kb) Multiome | 258 | |
| chr13:100,050,037–100,051,771 | 95.3 kb | Distal (>10kb) Multiome | 289 | |
| chr13:100,088,371–100,089,589 | 133.2 kb | Distal (>10kb) Multiome | 925 | |
| chr13:100,591,344–100,592,134 | 635.9 kb | Distal (>10kb) Multiome HiCAR | 51 |
Genomic view of the ENSG00000286757 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.