Transcription factors with Perturb-seq knockdown data for ENSG00000286492. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000286492 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000286492, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:111,852,502–111,853,012 | 7.7 kb | Proximal (<10kb) | 110 | |
| chr3:111,853,492–111,855,490 | 5.2 kb | Proximal (<10kb) | 162 | |
| chr3:111,855,622–111,856,225 | 4.5 kb | Proximal (<10kb) | 14 | |
| chr3:111,856,980–111,857,352 | 3.4 kb | Proximal (<10kb) | 8 | |
| chr3:111,858,752–111,861,061 | at TSS | At TSS | 807 | |
| chr3:111,862,347–111,862,979 | 1.6 kb | Proximal (<10kb) | 119 | |
| chr3:111,863,071–111,863,410 | 2.3 kb | Proximal (<10kb) | 37 | |
| chr3:111,863,555–111,863,748 | 2.8 kb | Proximal (<10kb) | 19 |
Genomic view of the ENSG00000286492 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.