Transcription factors with Perturb-seq knockdown data for ENSG00000286415. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000286415 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000286415, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:33,475,518–33,476,759 | 123.4 kb | Distal (>10kb) Multiome | 660 | |
| chr2:33,598,322–33,600,096 | 42 bp | At TSS Multiome | 951 | |
| chr2:33,607,152–33,607,883 | 8.0 kb | Proximal (<10kb) Multiome | 197 |
Genomic view of the ENSG00000286415 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.