Transcription factors with Perturb-seq knockdown data for ENSG00000286145. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000286145 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000286145, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:127,024,615–127,026,056 | 268.6 kb | Distal (>10kb) Multiome | 462 | |
| chr2:127,049,850–127,050,796 | 243.9 kb | Distal (>10kb) Multiome | 428 | |
| chr2:127,105,209–127,108,284 | 186.9 kb | Distal (>10kb) Multiome | 594 | |
| chr2:127,218,704–127,220,652 | 74.2 kb | Distal (>10kb) Multiome | 316 | |
| chr2:127,293,716–127,294,914 | 49 bp | At TSS Multiome | 876 | |
| chr2:127,296,282–127,296,529 | 2.1 kb | Proximal (<10kb) | 22 | |
| chr2:127,386,971–127,388,844 | 93.2 kb | Distal (>10kb) Multiome | 986 | |
| chr2:127,407,631–127,408,983 | 113.9 kb | Distal (>10kb) Multiome | 878 | |
| chr2:127,415,703–127,416,595 | 121.9 kb | Distal (>10kb) Multiome | 501 | |
| chr2:127,422,503–127,423,812 | 129.0 kb | Distal (>10kb) Multiome | 321 | |
| chr2:127,463,310–127,464,007 | 169.5 kb | Distal (>10kb) Multiome | 176 | |
| chr2:127,525,984–127,528,084 | 232.4 kb | Distal (>10kb) Multiome | 1026 | |
| chr2:127,542,311–127,543,476 | 249.0 kb | Distal (>10kb) Multiome | 233 | |
| chr2:127,591,279–127,591,967 | 297.4 kb | Distal (>10kb) Multiome | 431 |
Genomic view of the ENSG00000286145 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.