Transcription factors with Perturb-seq knockdown data for ENSG00000286039. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000286039 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000286039, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:173,500,912–173,501,687 | 8.0 kb | Proximal (<10kb) | 90 | |
| chr4:173,505,727–173,506,456 | 3.2 kb | Proximal (<10kb) | 215 | |
| chr4:173,506,646–173,507,174 | 2.5 kb | Proximal (<10kb) | 66 | |
| chr4:173,507,594–173,508,991 | 664 bp | At TSS | 118 | |
| chr4:173,509,260–173,509,947 | at TSS | At TSS | 195 | |
| chr4:173,510,504–173,510,851 | 848 bp | At TSS | 37 | |
| chr4:173,516,522–173,517,418 | 6.9 kb | Proximal (<10kb) | 182 | |
| chr4:173,517,533–173,518,354 | 7.9 kb | Proximal (<10kb) | 112 | |
| chr4:173,518,462–173,519,114 | 8.8 kb | Proximal (<10kb) | 140 |
Genomic view of the ENSG00000286039 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.