Transcription factors with Perturb-seq knockdown data for ENSG00000285835. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000285835 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000285835, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:88,041,789–88,041,975 | 3.6 kb | Proximal (<10kb) | 11 | |
| chr11:88,042,156–88,045,195 | 2.1 kb | Proximal (<10kb) Multiome | 271 | |
| chr11:88,045,330–88,046,584 | 519 bp | At TSS Multiome | 55 | |
| chr11:88,049,050–88,049,745 | 3.4 kb | Proximal (<10kb) | 77 | |
| chr11:88,103,338–88,104,240 | 58.3 kb | Distal (>10kb) Multiome | 281 | |
| chr11:88,174,680–88,176,137 | 129.8 kb | Distal (>10kb) Multiome | 513 | |
| chr11:88,297,316–88,298,087 | 252.1 kb | Distal (>10kb) Multiome | 228 | |
| chr11:88,301,008–88,301,969 | 255.7 kb | Distal (>10kb) Multiome | 249 | |
| chr11:88,308,509–88,309,240 | 263.0 kb | Distal (>10kb) Multiome | 175 | |
| chr11:88,337,232–88,338,805 | 292.2 kb | Distal (>10kb) Multiome | 823 |
Genomic view of the ENSG00000285835 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.