Transcription factors with Perturb-seq knockdown data for ENSG00000285664. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000285664 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000285664, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:52,551,688–52,554,284 | 239.1 kb | Distal (>10kb) Multiome | 899 | |
| chr14:52,694,713–52,696,105 | 96.0 kb | Distal (>10kb) Multiome | 749 | |
| chr14:52,706,745–52,707,707 | 84.6 kb | Distal (>10kb) Multiome | 713 | |
| chr14:52,729,614–52,730,927 | 61.7 kb | Distal (>10kb) Multiome | 803 | |
| chr14:52,790,881–52,792,384 | 62 bp | At TSS Multiome | 1077 | |
| chr14:52,827,263–52,828,172 | 35.9 kb | Distal (>10kb) Multiome | 103 | |
| chr14:52,835,079–52,835,883 | 43.6 kb | Distal (>10kb) Multiome | 369 | |
| chr14:52,852,332–52,854,201 | 61.5 kb | Distal (>10kb) Multiome | 475 | |
| chr14:52,950,305–52,952,252 | 159.5 kb | Distal (>10kb) Multiome HiCAR | 746 |
Genomic view of the ENSG00000285664 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.