Transcription factors with Perturb-seq knockdown data for ENSG00000284526. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000284526 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000284526, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:76,353,245–76,354,535 | 215.7 kb | Distal (>10kb) Multiome | 1071 | |
| chr17:76,383,686–76,385,081 | 185.1 kb | Distal (>10kb) Multiome | 823 | |
| chr17:76,385,493–76,386,382 | 183.6 kb | Distal (>10kb) Multiome | 935 | |
| chr17:76,452,469–76,453,735 | 116.4 kb | Distal (>10kb) Multiome | 726 | |
| chr17:76,500,907–76,502,333 | 68.2 kb | Distal (>10kb) Multiome | 728 | |
| chr17:76,506,248–76,506,840 | 63.2 kb | Distal (>10kb) Multiome | 550 | |
| chr17:76,537,326–76,538,627 | 31.9 kb | Distal (>10kb) Multiome | 192 | |
| chr17:76,540,451–76,541,323 | 28.7 kb | Distal (>10kb) Multiome | 478 | |
| chr17:76,557,376–76,557,942 | 12.0 kb | Distal (>10kb) Multiome | 906 | |
| chr17:76,585,404–76,586,417 | 16.2 kb | Distal (>10kb) Multiome | 591 | |
| chr17:76,612,985–76,613,550 | 43.6 kb | Distal (>10kb) Multiome | 308 | |
| chr17:76,671,049–76,672,200 | 102.1 kb | Distal (>10kb) Multiome | 947 | |
| chr17:76,708,018–76,708,518 | 138.5 kb | Distal (>10kb) Multiome | 236 | |
| chr17:76,710,928–76,711,574 | 141.4 kb | Distal (>10kb) Multiome | 421 | |
| chr17:76,725,921–76,727,506 | 157.0 kb | Distal (>10kb) Multiome | 1083 | |
| chr17:76,735,995–76,738,370 | 167.9 kb | Distal (>10kb) Multiome | 1227 | |
| chr17:76,868,004–76,869,024 | 298.7 kb | Distal (>10kb) Multiome | 481 |
Genomic view of the ENSG00000284526 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.