Transcription factors with Perturb-seq knockdown data for ENSG00000282048. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000282048 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000282048, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:113,758,781–113,760,075 | 272.9 kb | Distal (>10kb) Multiome | 889 | |
| chr1:113,811,244–113,812,738 | 220.0 kb | Distal (>10kb) Multiome | 978 | |
| chr1:113,904,394–113,905,850 | 127.2 kb | Distal (>10kb) Multiome | 1025 | |
| chr1:113,929,054–113,930,528 | 102.8 kb | Distal (>10kb) Multiome | 1003 | |
| chr1:113,978,866–113,979,713 | 53.0 kb | Distal (>10kb) Multiome | 426 | |
| chr1:114,031,872–114,032,790 | at TSS | At TSS | 88 | |
| chr1:114,033,158–114,033,578 | 782 bp | At TSS | 215 | |
| chr1:114,035,013–114,035,453 | 2.6 kb | Proximal (<10kb) | 56 | |
| chr1:114,037,114–114,037,804 | 4.9 kb | Proximal (<10kb) Multiome | 57 | |
| chr1:114,038,358–114,038,876 | 6.0 kb | Proximal (<10kb) | 45 | |
| chr1:114,152,319–114,153,141 | 120.4 kb | Distal (>10kb) Multiome HiCAR | 229 |
Genomic view of the ENSG00000282048 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.