Transcription factors with Perturb-seq knockdown data for ENSG00000281091. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000281091 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000281091, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:103,214,792–103,216,027 | 189.7 kb | Distal (>10kb) Multiome | 433 | |
| chrX:103,254,119–103,255,539 | 149.5 kb | Distal (>10kb) Multiome | 553 | |
| chrX:103,310,557–103,311,346 | 93.8 kb | Distal (>10kb) Multiome | 289 | |
| chrX:103,376,152–103,376,747 | 28.4 kb | Distal (>10kb) Multiome | 356 | |
| chrX:103,404,668–103,404,990 | at TSS | At TSS | 279 | |
| chrX:103,431,896–103,432,874 | 27.5 kb | Distal (>10kb) Multiome | 6 | |
| chrX:103,607,566–103,608,355 | 203.2 kb | Distal (>10kb) Multiome | 234 | |
| chrX:103,686,434–103,687,597 | 282.1 kb | Distal (>10kb) Multiome | 737 |
Genomic view of the ENSG00000281091 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.