Transcription factors with Perturb-seq knockdown data for ENSG00000279317. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000279317 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000279317, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:208,638,022–208,638,665 | 1533.3 kb | Distal (>10kb) Multiome HiCAR | 304 | |
| chr2:209,985,387–209,986,656 | 185.7 kb | Distal (>10kb) Multiome HiCAR | 197 | |
| chr2:210,002,022–210,003,279 | 169.0 kb | Distal (>10kb) Multiome | 811 | |
| chr2:210,169,996–210,172,503 | 182 bp | At TSS Multiome | 1015 | |
| chr2:210,177,699–210,178,146 | 6.2 kb | Proximal (<10kb) | 118 | |
| chr2:210,179,774–210,180,679 | 8.3 kb | Proximal (<10kb) | 40 | |
| chr2:210,181,086–210,182,197 | 9.6 kb | Proximal (<10kb) | 168 | |
| chr2:210,223,934–210,224,253 | 1.0 kb | Proximal (<10kb) | 9 | |
| chr2:210,224,566–210,225,799 | at TSS | At TSS | 493 | |
| chr2:210,476,213–210,477,273 | 305.1 kb | Distal (>10kb) Multiome | 848 |
Genomic view of the ENSG00000279317 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.