Transcription factors with Perturb-seq knockdown data for ENSG00000277619. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000277619 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000277619, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:135,027,489–135,027,710 | 6.8 kb | Proximal (<10kb) | 81 | |
| chr5:135,027,861–135,028,205 | 6.3 kb | Proximal (<10kb) | 79 | |
| chr5:135,028,731–135,029,454 | 5.1 kb | Proximal (<10kb) | 166 | |
| chr5:135,030,853–135,031,806 | 2.7 kb | Proximal (<10kb) | 138 | |
| chr5:135,032,878–135,033,426 | 1.1 kb | Proximal (<10kb) | 412 | |
| chr5:135,033,567–135,034,894 | at TSS | At TSS | 630 | |
| chr5:135,039,338–135,041,162 | 4.8 kb | Proximal (<10kb) | 207 |
Genomic view of the ENSG00000277619 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.