Transcription factors with Perturb-seq knockdown data for ENSG00000275038. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000275038 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000275038, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:171,307,254–171,307,622 | 2.2 kb | Proximal (<10kb) | 96 | |
| chr5:171,308,499–171,310,470 | at TSS | At TSS | 460 | |
| chr5:171,310,975–171,311,886 | 1.2 kb | Proximal (<10kb) | 164 | |
| chr5:171,311,985–171,312,893 | 2.2 kb | Proximal (<10kb) | 142 | |
| chr5:171,314,774–171,315,878 | 5.0 kb | Proximal (<10kb) | 97 | |
| chr5:171,316,120–171,317,100 | 6.3 kb | Proximal (<10kb) | 101 | |
| chr5:171,318,003–171,318,466 | 8.2 kb | Proximal (<10kb) | 24 |
Genomic view of the ENSG00000275038 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.