Transcription factors with Perturb-seq knockdown data for ENSG00000273674. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000273674 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000273674, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:49,154,953–49,156,105 | 1752.9 kb | Distal (>10kb) Multiome HiCAR | 952 | |
| chr15:50,686,025–50,687,320 | 221.8 kb | Distal (>10kb) Multiome | 976 | |
| chr15:50,765,134–50,766,102 | 143.1 kb | Distal (>10kb) Multiome | 890 | |
| chr15:50,900,796–50,901,063 | 7.5 kb | Proximal (<10kb) | 22 | |
| chr15:50,907,855–50,909,463 | 6 bp | At TSS Multiome | 953 | |
| chr15:51,069,431–51,069,998 | 161.0 kb | Distal (>10kb) Multiome | 105 | |
| chr15:51,076,952–51,078,202 | 168.9 kb | Distal (>10kb) Multiome | 330 | |
| chr15:51,093,930–51,095,030 | 186.0 kb | Distal (>10kb) Multiome | 325 |
Genomic view of the ENSG00000273674 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.