Transcription factors with Perturb-seq knockdown data for ENSG00000267952. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000267952 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000267952, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:7,500,843–7,501,401 | 5.6 kb | Proximal (<10kb) | 556 | |
| chr19:7,505,850–7,507,270 | at TSS | At TSS | 516 | |
| chr19:7,507,812–7,508,356 | 761 bp | At TSS | 168 | |
| chr19:7,512,387–7,512,812 | 5.3 kb | Proximal (<10kb) | 95 | |
| chr19:7,515,778–7,516,198 | 8.7 kb | Proximal (<10kb) | 463 |
Genomic view of the ENSG00000267952 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.