Transcription factors with Perturb-seq knockdown data for ENSG00000267698. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000267698 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000267698, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:35,716,025–35,718,811 | 296.8 kb | Distal (>10kb) Multiome | 1018 | |
| chr19:35,740,083–35,741,430 | 273.7 kb | Distal (>10kb) Multiome | 829 | |
| chr19:35,744,481–35,746,086 | 269.2 kb | Distal (>10kb) Multiome | 679 | |
| chr19:35,748,170–35,749,017 | 266.0 kb | Distal (>10kb) Multiome | 749 | |
| chr19:35,757,432–35,758,657 | 256.4 kb | Distal (>10kb) Multiome | 851 | |
| chr19:35,767,601–35,768,256 | 246.5 kb | Distal (>10kb) Multiome | 276 | |
| chr19:35,775,066–35,776,063 | 239.0 kb | Distal (>10kb) Multiome | 474 | |
| chr19:35,784,357–35,785,306 | 229.8 kb | Distal (>10kb) Multiome | 183 | |
| chr19:35,860,621–35,861,651 | 153.2 kb | Distal (>10kb) Multiome | 299 | |
| chr19:35,868,369–35,868,860 | 146.0 kb | Distal (>10kb) Multiome | 320 | |
| chr19:35,869,343–35,870,482 | 144.5 kb | Distal (>10kb) Multiome | 492 | |
| chr19:35,899,240–35,900,760 | 114.8 kb | Distal (>10kb) Multiome | 751 | |
| chr19:35,931,342–35,932,167 | 82.8 kb | Distal (>10kb) Multiome | 835 | |
| chr19:35,936,083–35,936,704 | 78.1 kb | Distal (>10kb) Multiome | 417 | |
| chr19:35,986,945–35,987,622 | 27.3 kb | Distal (>10kb) Multiome | 363 | |
| chr19:35,994,796–35,995,940 | 19.3 kb | Distal (>10kb) Multiome | 897 | |
| chr19:36,008,519–36,009,006 | 5.5 kb | Proximal (<10kb) | 427 | |
| chr19:36,009,229–36,009,633 | 4.9 kb | Proximal (<10kb) | 237 | |
| chr19:36,013,972–36,014,810 | 123 bp | At TSS Multiome | 623 | |
| chr19:36,032,424–36,033,187 | 18.4 kb | Distal (>10kb) Multiome | 179 | |
| chr19:36,053,782–36,055,591 | 40.0 kb | Distal (>10kb) Multiome | 1026 | |
| chr19:36,113,981–36,116,196 | 100.9 kb | Distal (>10kb) Multiome | 1052 | |
| chr19:36,127,575–36,128,707 | 113.5 kb | Distal (>10kb) Multiome | 942 | |
| chr19:36,139,425–36,141,811 | 125.4 kb | Distal (>10kb) Multiome | 1037 | |
| chr19:36,214,162–36,215,543 | 200.4 kb | Distal (>10kb) Multiome | 1008 | |
| chr19:36,245,106–36,245,849 | 231.0 kb | Distal (>10kb) Multiome | 153 |
Genomic view of the ENSG00000267698 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.