Transcription factors with Perturb-seq knockdown data for ENSG00000267002. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000267002 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000267002, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:42,964,237–42,964,843 | 205.8 kb | Distal (>10kb) Multiome | 655 | |
| chr17:42,979,966–42,981,044 | 189.9 kb | Distal (>10kb) Multiome | 843 | |
| chr17:42,997,598–42,998,917 | 172.0 kb | Distal (>10kb) Multiome | 1112 | |
| chr17:43,021,026–43,022,568 | 147.9 kb | Distal (>10kb) Multiome | 973 | |
| chr17:43,024,255–43,025,752 | 145.3 kb | Distal (>10kb) Multiome | 811 | |
| chr17:43,124,981–43,125,702 | 44.8 kb | Distal (>10kb) Multiome | 837 | |
| chr17:43,169,744–43,171,576 | 821 bp | At TSS Multiome | 1018 | |
| chr17:43,211,494–43,212,392 | 41.6 kb | Distal (>10kb) Multiome | 586 | |
| chr17:43,359,784–43,361,254 | 190.8 kb | Distal (>10kb) Multiome | 981 | |
| chr17:43,367,132–43,369,458 | 198.8 kb | Distal (>10kb) Multiome | 1146 | |
| chr17:43,388,101–43,389,658 | 219.1 kb | Distal (>10kb) Multiome | 770 | |
| chr17:43,396,555–43,396,987 | 226.4 kb | Distal (>10kb) Multiome | 27 | |
| chr17:43,398,359–43,400,469 | 228.6 kb | Distal (>10kb) Multiome | 827 | |
| chr17:43,403,154–43,404,714 | 233.6 kb | Distal (>10kb) Multiome | 252 | |
| chr17:43,406,748–43,407,604 | 236.9 kb | Distal (>10kb) Multiome | 102 | |
| chr17:43,438,695–43,439,408 | 268.7 kb | Distal (>10kb) Multiome | 86 | |
| chr17:43,457,977–43,459,063 | 288.2 kb | Distal (>10kb) Multiome | 328 |
Genomic view of the ENSG00000267002 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.