Transcription factors with Perturb-seq knockdown data for ENSG00000266446. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000266446 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000266446, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:21,989,523–21,990,203 | 5.3 kb | Proximal (<10kb) | 120 | |
| chr9:21,993,764–21,996,459 | at TSS | At TSS | 632 | |
| chr9:21,996,591–21,996,737 | 1.1 kb | Proximal (<10kb) | 71 | |
| chr9:22,005,147–22,006,417 | 9.7 kb | Proximal (<10kb) | 248 |
Genomic view of the ENSG00000266446 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.