Transcription factors with Perturb-seq knockdown data for ENSG00000262580. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000262580 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000262580, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:79,924,070–79,924,677 | 281.5 kb | Distal (>10kb) Multiome | 279 | |
| chr17:79,926,061–79,926,673 | 279.6 kb | Distal (>10kb) Multiome | 366 | |
| chr17:79,991,451–79,992,302 | 214.1 kb | Distal (>10kb) Multiome | 655 | |
| chr17:80,008,356–80,008,965 | 197.3 kb | Distal (>10kb) Multiome | 554 | |
| chr17:80,035,332–80,037,314 | 169.0 kb | Distal (>10kb) Multiome | 852 | |
| chr17:80,101,092–80,102,236 | 104.4 kb | Distal (>10kb) Multiome | 851 | |
| chr17:80,146,527–80,148,008 | 58.7 kb | Distal (>10kb) Multiome | 955 | |
| chr17:80,196,178–80,196,350 | 9.6 kb | Proximal (<10kb) | 324 | |
| chr17:80,219,620–80,221,064 | 14.5 kb | Distal (>10kb) Multiome | 809 | |
| chr17:80,260,016–80,260,559 | 54.4 kb | Distal (>10kb) Multiome | 677 | |
| chr17:80,260,789–80,261,746 | 55.6 kb | Distal (>10kb) Multiome | 896 | |
| chr17:80,308,064–80,309,516 | 102.4 kb | Distal (>10kb) Multiome | 193 | |
| chr17:80,376,366–80,377,013 | 170.8 kb | Distal (>10kb) Multiome | 75 | |
| chr17:80,407,766–80,408,220 | 202.0 kb | Distal (>10kb) Multiome | 12 | |
| chr17:80,414,488–80,415,786 | 209.4 kb | Distal (>10kb) Multiome | 964 | |
| chr17:80,426,748–80,427,205 | 221.1 kb | Distal (>10kb) Multiome | 529 | |
| chr17:80,454,454–80,455,448 | 248.9 kb | Distal (>10kb) Multiome | 1002 | |
| chr17:80,477,689–80,478,296 | 272.3 kb | Distal (>10kb) Multiome | 240 |
Genomic view of the ENSG00000262580 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.