Transcription factors with Perturb-seq knockdown data for ENSG00000262482. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000262482 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000262482, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:2,673,059–2,673,910 | 280.8 kb | Distal (>10kb) Multiome | 471 | |
| chr16:2,682,205–2,683,006 | 271.8 kb | Distal (>10kb) Multiome | 1003 | |
| chr16:2,720,741–2,721,896 | 233.0 kb | Distal (>10kb) Multiome | 758 | |
| chr16:2,751,637–2,753,398 | 201.7 kb | Distal (>10kb) Multiome | 1074 | |
| chr16:2,776,766–2,778,256 | 176.9 kb | Distal (>10kb) Multiome | 828 | |
| chr16:2,867,958–2,868,665 | 85.9 kb | Distal (>10kb) Multiome | 960 | |
| chr16:2,882,042–2,883,813 | 71.3 kb | Distal (>10kb) Multiome | 838 | |
| chr16:2,904,002–2,906,321 | 50.0 kb | Distal (>10kb) Multiome | 994 | |
| chr16:2,911,480–2,912,624 | 42.4 kb | Distal (>10kb) Multiome | 784 | |
| chr16:2,954,158–2,954,471 | at TSS | At TSS | 49 | |
| chr16:2,961,603–2,962,014 | 7.3 kb | Proximal (<10kb) | 334 | |
| chr16:2,963,159–2,965,475 | 9.7 kb | Proximal (<10kb) Multiome | 628 | |
| chr16:2,968,641–2,970,561 | 14.9 kb | Distal (>10kb) Multiome | 1039 | |
| chr16:2,979,651–2,981,140 | 26.2 kb | Distal (>10kb) Multiome | 795 | |
| chr16:2,981,390–2,982,257 | 27.5 kb | Distal (>10kb) Multiome | 460 | |
| chr16:3,003,612–3,004,589 | 49.8 kb | Distal (>10kb) Multiome | 652 | |
| chr16:3,007,583–3,008,956 | 54.2 kb | Distal (>10kb) Multiome | 514 | |
| chr16:3,017,242–3,018,799 | 63.9 kb | Distal (>10kb) Multiome | 451 | |
| chr16:3,019,969–3,022,268 | 66.0 kb | Distal (>10kb) Multiome | 963 | |
| chr16:3,022,890–3,024,532 | 69.9 kb | Distal (>10kb) Multiome | 933 | |
| chr16:3,027,854–3,029,038 | 74.1 kb | Distal (>10kb) Multiome | 546 | |
| chr16:3,045,413–3,047,408 | 91.9 kb | Distal (>10kb) Multiome | 510 | |
| chr16:3,058,226–3,060,102 | 105.1 kb | Distal (>10kb) Multiome | 769 | |
| chr16:3,098,550–3,100,475 | 146.0 kb | Distal (>10kb) Multiome | 454 | |
| chr16:3,106,146–3,106,906 | 152.4 kb | Distal (>10kb) Multiome | 851 | |
| chr16:3,123,818–3,124,940 | 170.1 kb | Distal (>10kb) Multiome | 800 | |
| chr16:3,134,425–3,135,445 | 180.7 kb | Distal (>10kb) Multiome | 752 | |
| chr16:3,149,357–3,151,137 | 196.4 kb | Distal (>10kb) Multiome | 975 | |
| chr16:3,152,009–3,153,129 | 198.5 kb | Distal (>10kb) Multiome | 889 | |
| chr16:3,158,260–3,159,345 | 204.6 kb | Distal (>10kb) Multiome | 764 | |
| chr16:3,182,514–3,183,488 | 228.6 kb | Distal (>10kb) Multiome | 690 | |
| chr16:3,187,874–3,189,822 | 235.2 kb | Distal (>10kb) Multiome | 679 | |
| chr16:3,234,780–3,235,610 | 281.0 kb | Distal (>10kb) Multiome | 845 |
Genomic view of the ENSG00000262482 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.