Transcription factors with Perturb-seq knockdown data for ENSG00000260808. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000260808 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000260808, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:68,459,835–68,461,497 | 156.2 kb | Distal (>10kb) Multiome | 1017 | |
| chr11:68,683,947–68,685,063 | 67.9 kb | Distal (>10kb) Multiome | 317 | |
| chr11:68,749,819–68,752,106 | 134.8 kb | Distal (>10kb) Multiome HiCAR | 601 | |
| chr11:68,839,165–68,839,925 | 222.7 kb | Distal (>10kb) Multiome | 821 | |
| chr11:68,840,765–68,842,245 | 225.2 kb | Distal (>10kb) Multiome | 567 | |
| chr11:68,843,712–68,844,382 | 227.3 kb | Distal (>10kb) Multiome | 675 | |
| chr11:68,855,267–68,855,945 | 238.8 kb | Distal (>10kb) Multiome | 230 | |
| chr11:68,879,344–68,879,843 | 262.8 kb | Distal (>10kb) Multiome | 69 | |
| chr11:68,903,762–68,904,282 | 287.2 kb | Distal (>10kb) Multiome | 1004 |
Genomic view of the ENSG00000260808 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.