Transcription factors with Perturb-seq knockdown data for ENSG00000259048. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000259048 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000259048, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:38,189,842–38,191,300 | 99.1 kb | Distal (>10kb) Multiome | 214 | |
| chr14:38,192,240–38,192,820 | 101.3 kb | Distal (>10kb) Multiome | 106 | |
| chr14:38,201,318–38,205,935 | 111.6 kb | Distal (>10kb) Multiome | 470 | |
| chr14:38,207,227–38,211,992 | 118.2 kb | Distal (>10kb) Multiome | 611 | |
| chr14:38,254,752–38,256,715 | 164.6 kb | Distal (>10kb) Multiome | 311 |
Genomic view of the ENSG00000259048 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.