Transcription factors with Perturb-seq knockdown data for ENSG00000258982. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000258982 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000258982, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:99,971,046–99,972,540 | 267.0 kb | Distal (>10kb) Multiome | 614 | |
| chr14:100,108,167–100,108,638 | 130.1 kb | Distal (>10kb) Multiome | 372 | |
| chr14:100,159,111–100,160,199 | 78.8 kb | Distal (>10kb) Multiome | 345 | |
| chr14:100,192,488–100,193,700 | 45.5 kb | Distal (>10kb) Multiome | 969 | |
| chr14:100,213,903–100,215,015 | 24.0 kb | Distal (>10kb) Multiome | 857 | |
| chr14:100,221,397–100,222,394 | 16.7 kb | Distal (>10kb) Multiome HiCAR | 448 | |
| chr14:100,237,942–100,240,742 | 163 bp | At TSS Multiome | 894 | |
| chr14:100,246,872–100,247,072 | 8.3 kb | Proximal (<10kb) | 238 | |
| chr14:100,284,345–100,286,145 | 46.9 kb | Distal (>10kb) Multiome | 894 | |
| chr14:100,304,634–100,307,624 | 66.5 kb | Distal (>10kb) Multiome | 725 | |
| chr14:100,318,097–100,318,705 | 79.9 kb | Distal (>10kb) Multiome | 363 | |
| chr14:100,348,695–100,349,830 | 110.8 kb | Distal (>10kb) Multiome | 195 | |
| chr14:100,371,470–100,372,320 | 133.4 kb | Distal (>10kb) Multiome | 99 | |
| chr14:100,372,706–100,373,117 | 134.4 kb | Distal (>10kb) Multiome | 79 | |
| chr14:100,375,470–100,376,763 | 137.8 kb | Distal (>10kb) Multiome | 889 | |
| chr14:100,393,734–100,394,422 | 155.5 kb | Distal (>10kb) Multiome | 66 |
Genomic view of the ENSG00000258982 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.