TFs regulating ENSG00000258670 0 TFs

Transcription factors with Perturb-seq knockdown data for ENSG00000258670. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000258670 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ENSG00000258670

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000258670, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr14:60,247,765–60,250,615	265.3 kb	Distal (>10kb) Multiome	1091
chr14:60,331,221–60,332,142	183.4 kb	Distal (>10kb) Multiome	515
chr14:60,485,178–60,486,252	29.2 kb	Distal (>10kb) Multiome	378
chr14:60,506,456–60,507,348	7.8 kb	Proximal (<10kb)	71
chr14:60,508,535–60,510,247	6.1 kb	Proximal (<10kb) Multiome	245
chr14:60,510,654–60,511,489	3.6 kb	Proximal (<10kb)	109
chr14:60,513,223–60,513,597	1.5 kb	Proximal (<10kb)	74
chr14:60,514,579–60,516,786	1.1 kb	Proximal (<10kb) Multiome	517
chr14:60,637,200–60,638,337	122.8 kb	Distal (>10kb) Multiome	201
chr14:60,641,851–60,643,218	127.3 kb	Distal (>10kb) Multiome HiCAR	222
chr14:60,648,454–60,651,189	134.5 kb	Distal (>10kb) Multiome HiCAR	790
chr14:60,655,802–60,657,953	142.2 kb	Distal (>10kb) Multiome HiCAR	631
chr14:60,720,299–60,724,768	206.7 kb	Distal (>10kb) Multiome	933

Genome Browser

Genomic view of the ENSG00000258670 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.