Transcription factors with Perturb-seq knockdown data for ENSG00000254951. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000254951 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000254951, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:7,672,897–7,674,787 | 232.4 kb | Distal (>10kb) Multiome | 379 | |
| chr11:7,905,555–7,906,470 | 157 bp | At TSS Multiome | 98 | |
| chr11:7,906,593–7,906,761 | 638 bp | At TSS | 38 | |
| chr11:7,909,636–7,910,173 | 3.8 kb | Proximal (<10kb) Multiome | 37 | |
| chr11:7,910,327–7,910,668 | 4.4 kb | Proximal (<10kb) | 29 | |
| chr11:7,986,569–7,987,645 | 81.2 kb | Distal (>10kb) Multiome HiCAR | 879 | |
| chr11:8,032,871–8,033,670 | 127.4 kb | Distal (>10kb) Multiome | 307 | |
| chr11:8,080,656–8,082,014 | 175.3 kb | Distal (>10kb) Multiome | 370 | |
| chr11:8,168,430–8,169,450 | 262.9 kb | Distal (>10kb) Multiome | 329 | |
| chr11:8,192,451–8,193,309 | 286.9 kb | Distal (>10kb) Multiome | 185 |
Genomic view of the ENSG00000254951 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.