Transcription factors with Perturb-seq knockdown data for ENSG00000254277. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000254277 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000254277, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:71,520,075–71,520,986 | 154.8 kb | Distal (>10kb) Multiome | 257 | |
| chr8:71,547,135–71,548,410 | 127.6 kb | Distal (>10kb) Multiome | 321 | |
| chr8:71,651,940–71,652,569 | 23.2 kb | Distal (>10kb) Multiome | 151 | |
| chr8:71,670,050–71,670,725 | 4.6 kb | Proximal (<10kb) | 114 | |
| chr8:71,671,847–71,672,784 | 2.9 kb | Proximal (<10kb) Multiome | 123 | |
| chr8:71,673,533–71,673,764 | 1.5 kb | Proximal (<10kb) | 21 | |
| chr8:71,674,695–71,676,017 | 71 bp | At TSS Multiome | 64 | |
| chr8:71,676,519–71,676,945 | 1.2 kb | Proximal (<10kb) | 12 | |
| chr8:71,677,078–71,677,458 | 1.8 kb | Proximal (<10kb) | 4 | |
| chr8:71,680,205–71,681,358 | 4.9 kb | Proximal (<10kb) | 179 | |
| chr8:71,687,309–71,688,683 | 12.9 kb | Distal (>10kb) Multiome | 165 | |
| chr8:71,706,258–71,707,055 | 31.4 kb | Distal (>10kb) Multiome | 124 | |
| chr8:71,715,807–71,716,840 | 41.1 kb | Distal (>10kb) Multiome | 170 | |
| chr8:71,841,631–71,842,524 | 166.7 kb | Distal (>10kb) Multiome | 218 | |
| chr8:71,843,237–71,844,888 | 168.7 kb | Distal (>10kb) Multiome | 479 |
Genomic view of the ENSG00000254277 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.