Transcription factors with Perturb-seq knockdown data for ENSG00000251615. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000251615 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000251615, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:8,157,851–8,159,668 | 199.4 kb | Distal (>10kb) Multiome | 635 | |
| chr4:8,242,133–8,242,751 | 115.9 kb | Distal (>10kb) Multiome | 482 | |
| chr4:8,269,411–8,270,406 | 88.5 kb | Distal (>10kb) Multiome | 248 | |
| chr4:8,427,739–8,429,898 | 71.3 kb | Distal (>10kb) Multiome | 796 | |
| chr4:8,435,765–8,436,370 | 77.7 kb | Distal (>10kb) Multiome | 58 | |
| chr4:8,437,244–8,438,165 | 79.4 kb | Distal (>10kb) Multiome | 79 | |
| chr4:8,440,272–8,441,421 | 82.4 kb | Distal (>10kb) Multiome | 843 | |
| chr4:8,559,567–8,561,304 | 201.6 kb | Distal (>10kb) Multiome | 152 | |
| chr4:8,567,886–8,568,408 | 209.9 kb | Distal (>10kb) Multiome | 46 | |
| chr4:8,580,009–8,581,204 | 222.3 kb | Distal (>10kb) Multiome | 591 | |
| chr4:8,592,223–8,593,386 | 234.4 kb | Distal (>10kb) Multiome | 263 | |
| chr4:8,607,476–8,608,065 | 249.4 kb | Distal (>10kb) Multiome | 216 |
Genomic view of the ENSG00000251615 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.