Transcription factors with Perturb-seq knockdown data for ENSG00000250602. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000250602 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000250602, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:126,368,229–126,369,139 | 121.8 kb | Distal (>10kb) Multiome | 331 | |
| chr5:126,422,966–126,423,868 | 67.0 kb | Distal (>10kb) Multiome | 621 | |
| chr5:126,490,259–126,490,841 | at TSS | At TSS | 131 | |
| chr5:126,499,879–126,500,265 | 9.5 kb | Proximal (<10kb) | 100 | |
| chr5:126,591,477–126,591,957 | 101.3 kb | Distal (>10kb) Multiome | 61 | |
| chr5:126,594,453–126,595,707 | 104.9 kb | Distal (>10kb) Multiome | 803 | |
| chr5:126,599,987–126,601,746 | 110.5 kb | Distal (>10kb) Multiome | 911 | |
| chr5:126,747,828–126,748,496 | 257.9 kb | Distal (>10kb) Multiome | 495 | |
| chr5:126,776,292–126,778,844 | 286.6 kb | Distal (>10kb) Multiome | 1113 |
Genomic view of the ENSG00000250602 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.