Transcription factors with Perturb-seq knockdown data for ENSG00000248752. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000248752 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000248752, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:124,752,974–124,753,601 | 1615.5 kb | Distal (>10kb) Multiome HiCAR | 193 | |
| chr5:126,317,233–126,317,918 | 51.2 kb | Distal (>10kb) Multiome | 47 | |
| chr5:126,368,229–126,369,139 | at TSS | At TSS | 331 | |
| chr5:126,369,793–126,370,509 | 1.0 kb | Proximal (<10kb) | 236 | |
| chr5:126,422,966–126,423,868 | 54.6 kb | Distal (>10kb) Multiome | 621 | |
| chr5:126,594,453–126,595,707 | 226.5 kb | Distal (>10kb) Multiome | 803 | |
| chr5:126,599,987–126,601,746 | 232.2 kb | Distal (>10kb) Multiome | 911 |
Genomic view of the ENSG00000248752 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.