Transcription factors with Perturb-seq knockdown data for ENSG00000248605. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000248605 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000248605, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:25,415,591–25,416,356 | 6.5 kb | Proximal (<10kb) | 16 | |
| chr5:25,416,481–25,416,781 | 6.1 kb | Proximal (<10kb) | 25 | |
| chr5:25,418,366–25,418,936 | 3.9 kb | Proximal (<10kb) | 25 | |
| chr5:25,421,278–25,421,872 | 982 bp | At TSS | 14 | |
| chr5:25,448,057–25,449,021 | 25.5 kb | Distal (>10kb) Multiome | 174 |
Genomic view of the ENSG00000248605 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.