Transcription factors with Perturb-seq knockdown data for ENSG00000247134. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000247134 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000247134, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:32,927,696–32,928,504 | 3 bp | At TSS Multiome | 353 | |
| chr8:33,120,207–33,121,079 | 192.8 kb | Distal (>10kb) Multiome | 177 | |
| chr8:33,147,470–33,149,353 | 221.0 kb | Distal (>10kb) Multiome | 106 | |
| chr8:33,187,460–33,188,474 | 260.1 kb | Distal (>10kb) Multiome | 176 | |
| chr8:33,223,201–33,224,129 | 295.6 kb | Distal (>10kb) Multiome | 103 |
Genomic view of the ENSG00000247134 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.