Transcription factors with Perturb-seq knockdown data for ENSG00000246250. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000246250 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000246250, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:43,643,882–43,644,534 | 236.5 kb | Distal (>10kb) Multiome | 809 | |
| chr11:43,680,105–43,681,375 | 200.1 kb | Distal (>10kb) Multiome | 774 | |
| chr11:43,880,452–43,881,136 | 62 bp | At TSS Multiome | 939 | |
| chr11:43,890,306–43,890,462 | 9.6 kb | Proximal (<10kb) | 104 | |
| chr11:43,942,022–43,943,596 | 61.8 kb | Distal (>10kb) Multiome | 499 | |
| chr11:44,065,829–44,066,798 | 185.5 kb | Distal (>10kb) Multiome | 696 | |
| chr11:44,078,830–44,079,335 | 198.3 kb | Distal (>10kb) Multiome | 60 | |
| chr11:44,095,519–44,096,650 | 215.1 kb | Distal (>10kb) Multiome | 621 |
Genomic view of the ENSG00000246250 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.