Transcription factors with Perturb-seq knockdown data for ENSG00000239381. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000239381 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000239381, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:181,694,870–181,696,497 | 4.1 kb | Proximal (<10kb) | 327 | |
| chr3:181,698,205–181,698,506 | 2.1 kb | Proximal (<10kb) | 40 | |
| chr3:181,699,591–181,699,969 | 641 bp | At TSS | 68 | |
| chr3:181,700,134–181,701,495 | at TSS | At TSS | 431 | |
| chr3:181,701,594–181,702,555 | 983 bp | At TSS | 283 | |
| chr3:181,704,516–181,705,421 | 3.9 kb | Proximal (<10kb) | 135 | |
| chr3:181,707,992–181,708,401 | 7.4 kb | Proximal (<10kb) | 140 | |
| chr3:181,709,626–181,710,028 | 9.0 kb | Proximal (<10kb) | 249 | |
| chr3:181,710,172–181,713,363 | 9.6 kb | Proximal (<10kb) | 617 |
Genomic view of the ENSG00000239381 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.