Transcription factors with Perturb-seq knockdown data for ENSG00000237356. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000237356 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000237356, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:52,950,305–52,952,252 | 266.4 kb | Distal (>10kb) Multiome | 746 | |
| chr14:53,151,675–53,153,814 | 64.3 kb | Distal (>10kb) Multiome | 835 | |
| chr14:53,180,073–53,181,385 | 36.6 kb | Distal (>10kb) Multiome | 192 | |
| chr14:53,217,268–53,218,117 | 13 bp | At TSS Multiome | 507 | |
| chr14:53,355,345–53,356,164 | 138.2 kb | Distal (>10kb) Multiome | 363 |
Genomic view of the ENSG00000237356 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.