Transcription factors with Perturb-seq knockdown data for ENSG00000236212. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000236212 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000236212, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:33,939,006–33,939,864 | 270.1 kb | Distal (>10kb) Multiome | 113 | |
| chr7:33,945,850–33,946,487 | 263.2 kb | Distal (>10kb) Multiome | 74 | |
| chr7:34,205,649–34,206,468 | 3.0 kb | Proximal (<10kb) | 44 | |
| chr7:34,320,797–34,321,709 | 111.8 kb | Distal (>10kb) Multiome | 410 | |
| chr7:34,387,315–34,388,254 | 178.4 kb | Distal (>10kb) Multiome | 60 |
Genomic view of the ENSG00000236212 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.