Transcription factors with Perturb-seq knockdown data for ENSG00000235979. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000235979 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000235979, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:19,237,368–19,238,388 | 218.9 kb | Distal (>10kb) Multiome | 509 | |
| chr17:19,317,172–19,317,657 | 138.9 kb | Distal (>10kb) Multiome | 467 | |
| chr17:19,362,100–19,363,673 | 93.4 kb | Distal (>10kb) Multiome | 804 | |
| chr17:19,377,561–19,379,155 | 78.0 kb | Distal (>10kb) Multiome | 877 | |
| chr17:19,386,868–19,387,884 | 69.0 kb | Distal (>10kb) Multiome | 305 | |
| chr17:19,433,247–19,433,662 | 22.8 kb | Distal (>10kb) Multiome | 30 | |
| chr17:19,455,896–19,456,558 | 141 bp | At TSS Multiome | 43 | |
| chr17:19,457,529–19,459,378 | 1.8 kb | Proximal (<10kb) Multiome | 100 | |
| chr17:19,460,682–19,461,395 | 4.9 kb | Proximal (<10kb) Multiome | 93 | |
| chr17:19,492,967–19,493,199 | at TSS | At TSS | 35 | |
| chr17:19,507,283–19,508,789 | 51.8 kb | Distal (>10kb) Multiome | 842 | |
| chr17:19,519,787–19,520,274 | 63.6 kb | Distal (>10kb) Multiome | 130 | |
| chr17:19,533,700–19,534,412 | 77.6 kb | Distal (>10kb) Multiome | 488 | |
| chr17:19,579,724–19,580,220 | 123.6 kb | Distal (>10kb) Multiome | 101 | |
| chr17:19,645,969–19,646,517 | 189.8 kb | Distal (>10kb) Multiome | 116 | |
| chr17:19,647,149–19,649,280 | 191.2 kb | Distal (>10kb) Multiome | 1126 | |
| chr17:19,744,539–19,745,417 | 288.7 kb | Distal (>10kb) Multiome | 325 |
Genomic view of the ENSG00000235979 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.