Transcription factors with Perturb-seq knockdown data for ENSG00000235934. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000235934 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000235934, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:170,812,804–170,813,447 | 4.4 kb | Proximal (<10kb) | 233 | |
| chr2:170,813,589–170,814,073 | 3.8 kb | Proximal (<10kb) | 79 | |
| chr2:170,814,174–170,814,458 | 3.4 kb | Proximal (<10kb) | 248 | |
| chr2:170,814,981–170,816,480 | 1.4 kb | Proximal (<10kb) | 523 | |
| chr2:170,816,723–170,818,614 | at TSS | At TSS | 458 | |
| chr2:170,819,935–170,820,669 | 2.0 kb | Proximal (<10kb) | 95 | |
| chr2:170,820,955–170,821,457 | 3.1 kb | Proximal (<10kb) | 120 | |
| chr2:170,822,131–170,822,619 | 4.2 kb | Proximal (<10kb) | 105 | |
| chr2:170,823,170–170,823,953 | 5.3 kb | Proximal (<10kb) | 223 |
Genomic view of the ENSG00000235934 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.