Transcription factors with Perturb-seq knockdown data for ENSG00000235152. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000235152 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000235152, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:231,941,835–231,942,383 | 218.0 kb | Distal (>10kb) Multiome | 87 | |
| chr1:232,057,279–232,058,822 | 102.0 kb | Distal (>10kb) Multiome | 61 | |
| chr1:232,110,486–232,111,379 | 49.2 kb | Distal (>10kb) Multiome | 267 | |
| chr1:232,166,891–232,167,237 | 6.8 kb | Proximal (<10kb) | 46 | |
| chr1:232,226,207–232,226,650 | 66.3 kb | Distal (>10kb) Multiome | 187 | |
| chr1:232,352,018–232,353,153 | 192.6 kb | Distal (>10kb) Multiome | 118 |
Genomic view of the ENSG00000235152 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.