Transcription factors with Perturb-seq knockdown data for ENSG00000234405. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000234405 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000234405, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:103,214,792–103,216,027 | 275.4 kb | Distal (>10kb) Multiome | 433 | |
| chrX:103,254,119–103,255,539 | 235.2 kb | Distal (>10kb) Multiome | 553 | |
| chrX:103,310,557–103,311,346 | 179.5 kb | Distal (>10kb) Multiome | 289 | |
| chrX:103,376,152–103,376,747 | 114.2 kb | Distal (>10kb) Multiome | 356 | |
| chrX:103,431,896–103,432,874 | 58.2 kb | Distal (>10kb) Multiome | 6 | |
| chrX:103,481,027–103,481,285 | 9.3 kb | Proximal (<10kb) | 18 | |
| chrX:103,607,566–103,608,355 | 117.5 kb | Distal (>10kb) Multiome | 234 | |
| chrX:103,686,434–103,687,597 | 196.3 kb | Distal (>10kb) Multiome | 737 | |
| chrX:103,766,973–103,767,614 | 276.7 kb | Distal (>10kb) Multiome | 82 |
Genomic view of the ENSG00000234405 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.